Soyselect^® has been tested in three different clinical trials at dosages ranging from 400 to 640 mg/day, to evaluate its efficacy in the management of menopause-related symptoms.

The overall figure of the effects of Soyselect^® can be summarized as follow:

Vasomotor symptoms relief in post-menopausal women (400 mg/day) (1,2):

a double-blind randomized pilot study has been performed to comparatively evaluate, on 39 postmenopausal women, the activity of Soyselect^® and placebo on early climacteric symptoms, with a significative reduction of the number of hot flushes (-45% after 5 weeks of treatment with Soyselect^®, chart 1).

another double-blind, randomized, parallel group, outpatient, multicenter (15 sites) study has been performed on 177 postmenopausal women, with a significative reduction of incidence and severity of hot flushes (-32% at week 10) and number of awakenings due to night sweats (-62% at week 12, chart 2).



Improvement of cognitive function in older women (640 mg/day) (3):

a 6-month, double-blind, randomized, placebo-controlled clinical trial has been performed on 56 postmenopausal women. The postmenopausal women treated with Soyselect^® did consistently better, both in comparison with their own baseline scores and with the placebo group responses at 6 months (chart 3).

(1) Scambia G., Mango D., Signorile P.G., Anselmi Angeli R., Palena C., Gallo D., Bombardelli E., Morazzoni P., Riva A., Mancuso S., "Clinical effects of a standardized soy extract in postmenopausal women: a pilot study", Menopause Mar-Apr;7(2):105-11 (2000)
(2) Upmalis D.H., Lobo R., Bradley L., Warren M., Cone F.L., Lamia C.A., "Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study", Menopause Jul-Aug;7(4):236-42 (2000).
(3) Kritz-Silverstein D., Von Mühlen D., Barrett-Connor E., Bressel M.A.B., "Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study", Menopause May-Jun;10(3):196-202 (2003).